FOXO4 (10mg)

$299.99

FOXO4-DRI is a D-retro-inverso peptide studied in cellular senescence and p53-interaction research models. Lyophilized powder for laboratory research use only.

We Accept:
Accepted payment methods at Aurevena
Certificate of Analysis
DOWNLOAD

Fast Fulfillment

Ships with 1-2 business days

Research Guarantee

Damaged on arrival. Replaced

$150 + Free Shipping

Fast & Tracked

U.S. Third-Party Tested

COA available for each product

Independently Verified. Every Batch

Every Aurevena product is sent to an independent, accredited third-party laboratory before it is offered for sale. Certificates of Analysis confirm compound identity, purity percentage, and the absence of harmful contaminants.

COAs are published by lot number so researchers can verify the exact product they receive. We do not sell any product that does not clear our purity threshold.

  • Compound identity (HPLC / MS verification)
  • Purity percentage (target ≥ 99%)
  • Absence of heavy metals
  • Lot-number traceability
CERTIFICATE OF ANALYSIS

FOXO4 (10mg)

10mg

PURITY 99.50%%
ASSAY 10.3mg
IDENTITY Confirmed
HEAVY METALS <10 ppb
TAMC 0 CFU
TYMC 0 CFU
BATCH/LOT 20251220L05F4S10
DOWNLOAD COA

Description

FOXO4-DRI is a D-retro-inverso peptide designed to interfere with the interaction between the transcription factor FOXO4 and the tumor-suppressor protein p53, making it a prominent tool compound in cellular-senescence research. Laboratory investigators study FOXO4-DRI for its role in disrupting FOXO4-p53 binding, modeling senescent-cell signaling, and probing senolytic mechanisms in vitro and in preclinical systems. Supplied for in-vitro and laboratory research only — not for human or veterinary use.

Compound ClassSynthetic retro-inverso D-amino acid peptide (FOXO4-DRI)
CAS NumberNot assigned
Molecular FormulaVariable depending on synthesis
Molecular WeightApproximately 2.9 kDa
SequenceRetro-inverso D-amino acid peptide derived from FOXO4-p53 binding interface (full sequence in scientific literature)
AppearanceWhite to off-white lyophilized powder

Research Overview

Used in in vitro and preclinical research relating to FOXO transcription factor chemistry and senescent cell biology studies.

Storage

Store unreconstituted vials refrigerated at 2-8°C and long-term at -20°C; once reconstituted, store at 2-8°C and use within 30 days.

IMPORTANT RESEARCH NOTICE

Not for human consumption.

This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

Frequently Asked Questions

Lyophilized (powder) peptides should be stored at -20°C for long-term storage or 2-8°C (refrigerator) for short-term. Always protect from light and avoid repeated freeze-thaw cycles.
We offer damage protection on every order. If your product arrives damaged in transit, contact us with photos for a one-time replacement. All claims require photo evidence and are subject to review. One replacement per customer per order. Reconstituted products are not eligible. We do not offer refunds for change of mind or misuse.
Yes, every batch is tested by independent, accredited U.S. laboratories for purity verification and Mass Spectrometry for identity confirmation. Test results are published on each product page as Certificates of Analysis (CoA).
Orders are processed within 1-2 business days. Standard shipping typically arrives within 3-5 business days from fulfillment. Express and overnight options are available at checkout. Every order includes free shipment protection.
Currently, we ship within the United States only. We're working on expanding our shipping capabilities to serve researchers worldwide.
Orders can be modified or canceled within 5 min of placement. After this window, orders enter processing and cannot be changed. Contact hello@aurevenaresearch.com immediately if you need to make changes.
We offer damage protection on every order. If your product arrives damaged in transit, contact us with photos for a one-time replacement. All claims require photo evidence and are subject to review. One replacement per customer per order. Reconstituted products are not eligible. We do not offer refunds for change of mind or misuse.

Recently Viewed

Sources & References

Peer-reviewed research

CELLULAR RESEARCHFOXO4 (10mg)3 SOURCES
Cell

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

VOL 169(1):132-147.e16 · PMID 28340339 · DOI 10.1016/j.cell.2017.02.031
Baar MP, Brandt RMC, Putavet DA, et al. (de Keizer PLJ) · 2017
Nat Commun

The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

VOL 16(1):5672 · PMID 40593617 · DOI 10.1038/s41467-025-60844-9
Bourgeois B, Spreitzer E, Platero-Rochart D, et al. · 2025
Commun Biol

FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

VOL 8(1):299 · PMID 39994346 · DOI 10.1038/s42003-025-07738-0
Kong YX, Li ZS, Liu YB, et al. · 2025

Research FAQ

Compound and research-use information

What is FOXO4-DRI?

FOXO4-DRI is a synthetic D-retro-inverso peptide designed to disrupt the FOXO4-p53 protein interaction in research models. It is supplied as a research chemical.

What is FOXO4-DRI studied for in the research setting?

FOXO4-DRI is used in vitro and in preclinical cellular-senescence research to study the FOXO4-p53 interaction and senescent-cell biology. It is a mechanistic research tool used in senescence and cell-aging models.

What form is Aurevena's FOXO4-DRI supplied in?

FOXO4-DRI is supplied as a lyophilized (freeze-dried) powder. Every batch is tested by independent, accredited U.S. laboratories for purity and identity, with the Certificate of Analysis published on this product page. Store lyophilized peptide cold and protected from light, and avoid repeated freeze-thaw cycles.

Is FOXO4-DRI intended for human use?

No. FOXO4-DRI is sold by Aurevena strictly for laboratory and research use only. It is not a drug, dietary supplement, cosmetic, or medical device, and is not intended for human or veterinary use, consumption, or for the diagnosis, treatment, cure, or prevention of any disease.