Sources & References
Peer-reviewed research
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Research FAQ
Compound and research-use information
What is FOXO4-DRI?
FOXO4-DRI is a synthetic D-retro-inverso peptide designed to disrupt the FOXO4-p53 protein interaction in research models. It is supplied as a research chemical.
What is FOXO4-DRI studied for in the research setting?
FOXO4-DRI is used in vitro and in preclinical cellular-senescence research to study the FOXO4-p53 interaction and senescent-cell biology. It is a mechanistic research tool used in senescence and cell-aging models.
What form is Aurevena's FOXO4-DRI supplied in?
FOXO4-DRI is supplied as a lyophilized (freeze-dried) powder. Every batch is tested by independent, accredited U.S. laboratories for purity and identity, with the Certificate of Analysis published on this product page. Store lyophilized peptide cold and protected from light, and avoid repeated freeze-thaw cycles.
Is FOXO4-DRI intended for human use?
No. FOXO4-DRI is sold by Aurevena strictly for laboratory and research use only. It is not a drug, dietary supplement, cosmetic, or medical device, and is not intended for human or veterinary use, consumption, or for the diagnosis, treatment, cure, or prevention of any disease.





